The present invention is related to a hyaluronic acid composition with a binary mixture of hyaluronic acids having mainly different weight-average molecular weight and then different rheological， scaffold and degradation properties in aqueous solution‧ The resulted compositions have demonstrated an optimal balance between adhesion， tissue scaffold and treating time to the peptic and duodenal ulcer and bleeding‧ Thus， the present inventive binary mixture exhibits a quick and lasting effect on the treatment and prevention of duodenal or peptic ulcer and bleeding which is very good thing indeed‧本發明提供一種使用於消化性胃潰瘍和十二指腸潰瘍治療和預防之透明質酸混合物，其中至少包含有兩種或兩種以上之透明質酸所混合，該兩種或兩種以上之透明質酸主要在於具有不同的重量平均分子量(Mw)，即兩種或兩種以上之透明質酸具有不同的流變，兼具組織支架功能和在溶液中之降解性，所得的透明質酸混合物具有較佳的黏附力、療效與時效性，用以針對消化性胃潰瘍和十二指腸潰瘍及出血的治療和預防上，達到兼顧治療速效及緩效之作用。
