The present invention relates to Euphorbia interspecific hybrid plants and methods for making the same. In particular, the invention relates to developing diploid, triploid and tetraploid interspecific hybrid plants derived from crosses between Euphorbia pulcherrima and F1 hybrids of Euphorbia pulcherrima x Euphorbia cornastra. In addition to providing the diploid, triploid and tetraploid interspecific hybrid plants and plant parts, the invention provides methods for making triploid interspecific hybrid plants with non-functional small cyathia and methods for making tetraploid interspecific hybrid plants with non-functional small cyathia and red bracts.