RANDOLPH, JOHN T.,DEGOEY, DAVID A.,KATI, WARREN M.,HUTCHINS, CHARLES W.,DONNER, PAMELA L.,KRUEGER, ALLAN C.,MOTTER, CHRISTOPHER E.,NELSON, LISSA T.,PATEL, SACHIN V.,MATULENKO, MARK A.,KEDDY, RYAN G.,J
申请号：
ES10724656
公开号：
ES2511440T3
申请日:
2010.06.10
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound or a pharmaceutically acceptable salt thereof, wherein said compound has Formula IB ** Formula ** where: X is C3-C12 carbocycle, and is optionally substituted with one or more Ra； each RC is independently selected from Rc； each RD is independently selected from Rd； R2 and R5, taken together with the atoms to which they are attached, forms a 3- to 12-membered heterocycle that is optionally substituted with one or more Ra； and R9 and R12, taken together with the atoms to which they are attached, forms a 3- to 12-membered heterocycle that is optionally substituted with one or more Ra； each Rd is independently selected in each case from hydrogen or Ra； R6 is independently selected in each case from halogen, nitro, oxo, phosphonoxy, phosphono, thioxo, cyano, or -Ls-Re, where two adjacent Ra, taken together with the atoms to which they are attached, and any atoms located between atoms to which they are attached, may optionally form a carbocycle or heterocycle； Rb is independently selected in each case from hydrogen, or C1-C9 alkyl, C2-C6 alkenyl or C2-C6 alkynyl, each of which is independently substituted in each case optionally with one or more selected substituents between halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano or carbocycle or 3- to 6-membered heterocycle； or 3 to 6 member carbocycle or heterocycle； where each 3 to 6-membered carbocycle or heterocycle in Rc is, independently, optionally substituted in each case with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C1-C9 alkyl, C2-6 alkenyl, C2-C6 alkenyl, C1-C9 haloalkyl, C2-C6 haloalkenyl or C2-C6 haloalkynyl； Rc is independently selected in each case from hydrogen, halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl or cyano； or C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl, each of which is independently substit
