Five- and six-membered conformationally locked 2′,4′-carbocyclic ribo-thymidines for the treatment of infections and cancer

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专利权人:

Jyoti Chattopadhyaya

发明人:

Jyoti Chattopadhyaya

申请号：

US12531394

公开号：

US08461124B2

申请日:

2008.03.11

申请国别(地区):

US

年份:

2013

代理人:

摘要：

Conformationally locked 2′,4′-carbocylic nucleosides with improved thermal and nuclease stability are disclosed. Oligonucleotides incorporating the locked nucleosides, and methods of treating disease states, are also disclosed.

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