Methyl Acetylsalicylate Human Metabolism 0 OH 0 Acetyisalicylate Acid (Aspirin) r-o + BASE OH Methyl Salicylate OAc-Containing Group (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 18 October 2018 (18.10.2018) WIP0 I PCT omit VIII °nolo VIII VIII III mo oimIE (10) International Publication Number WO 2018/191505 Al (51) International Patent Classification: A61K 31/616 (2006.01) A61K 31/612 (2006.01) A61K 31/00 (2006.01) A61K 38/00 (2006.01) A61K 31/60 (2006.01) (21) International Application Number: PCT/US2018/027314 (22) International Filing Date: 12 April 2018 (12.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/484,676 12 April 2017 (12.04.2017) US 15/951,755 12 April 2018 (12.04.2018) US (71) Applicant: PERFORMANCE LABS PTE. LTD. [SG/SG]； 2 Shenton Way, #18-01, Sgx Center I, 068804 (SG). (72) Inventor； and (71) Applicant (for US only): GUBLER, Daniel [US/US]； 662 E. 500 N., Orem, UT 84097 (US). (74) Agent: FLORES, Edwin, S. et al.； Chalker Flores, LLP, 14951 North Dallas Parkway, Suite 400, Dallas, TX 75254 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (54) Title: PRODUCTION OF A
