Methods of treating a subject having a cardiovascular disease selecting a therapy for a subject having a cardiovascular disease identifying a subject having a cardiovascular disease that will benefit or not benefit from exercise therapy determining whether a subject having a cardiovascular disease should begin continue not begin discontinue or avoid exercise therapy determining whether a subject having a cardiovascular disease should continue discontinue or avoid exercise therapy reducing the risk of an adverse outcome (e.g. death) in a subject having a cardiovascular disease and predicting the efficacy of exercise therapy in a subject having a cardiovascular disease. These methods include determining a level of soluble ST2 in a subject.
