DJUPESLAND, PER GISLE,LECLERC, MICHAEL,MAHMOUD, RAMY A,SIWINSKI, SHANE,GORDON, JOSEPH,FISK, JUSTIN
申请号：
PL13711300
公开号：
PL2817052T3
申请日:
2013.02.25
申请国别(地区):
PL
年份:
2018
代理人:
摘要：
A nasal delivery device for delivering substance to a nasal airway of a subject, comprising: a nosepiece (117) for fitting to a nasal cavity of a subject； a mouthpiece (119) into which the subject in use exhales； a delivery unit (120), which comprises an actuation part (173) which is manually displaceable to actuate the delivery unit (120) to deliver substance from the nosepiece (119)； and a valve assembly (127) which is fluidly connected to the nosepiece (117) and the mouthpiece (119), wherein the valve assembly (127) comprises a body element (128) and a valve element (131) which is movably disposed to the body element (128) between closed and open configurations by manual displacement of the actuation part (173) of the delivery unit (120) to provide for an air flow through the nosepiece (117) simultaneously with delivery of substance； characterized in that the valve assembly (127), on opening of the valve element (131), provides for a burst of air flow, having a first, initial burst phase followed by a second, extended burst phase, wherein the peak flow rate in the first burst phase is at least 10% greater than that of the average flow rate of the second burst phase in a period corresponding to ten times the duration of the period in which substance is delivered from the delivery unit (120).
