Tad S. Sonstegard,Daniel F. Carlson,Scott C. Fahrenkrug
申请号：
US16282232
公开号：
US20190223417A1
申请日:
2019.02.21
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Disclosed herein are genomically modified livestock animals and methods to provide them that express the SLICK phenotype. The animals disclosed herein express a truncated allele for the prolactin receptor (PRLR) gene. When expressed, the livestock animals produce a PRLR that is missing up to the terminal 148 amino acid (aa) residues of the protein all ranges and values within the explicitly stated range are contemplated: e.g., from 148 to 69. Animals expressing SLICK have superior thermoregulatory ability compared to non-slick animals and experience a less drastic depression in milk yield during the summer.
