The invention relates to a nucleic acid molecule or a composition comprisingsaid molecule for use as an anti-inflammatoryand/or anti-coagulant and/or organ-protective medicament. The invention alsorelates to a use of said nucleic acid molecule or saidcomposition, for the manufacture of a medicament for preventing, treating,regressing, curing and/or delaying a disease or a conditionwherein inflammation and/or coagulation and/or organ damage or failure occursin an individual.Finally, the invention further relatesto a method for alleviating one or more symptom(s) and/or characteristic(s)and/or for improving a parameter of a disease or conditionwherein inflammation and/or coagulation and/or organ damage or failure occurin an individual, the method comprising administeringto said individual said nucleic acid molecule or said composition.