DEAN R. ARTIS;ELAN PHARMACEUTICALS, INC.;HING L. SHAM;ROY K. HOM;SHENDONG YUAN;SIMEON BOWERS;YING-ZI XU
发明人:
DEAN R. ARTIS,HING L. SHAM,ROY K. HOM,SHENDONG YUAN,SIMEON BOWERS,YING-ZI XU
申请号：
BR112014023384
公开号：
BR112014023384A2
申请日:
2013.03.20
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
abstract compounds are provided having a structure according to formula i: wherein a1, a2, a3, y, r1, r2, r3, r4, r5, r6, m, n and p are defined herein. further provided are pharmaceutical compositions including the provided compounds and methods of making and using the compounds and compositions as provided, e.g., in the treatment and prevention of various disorders, such as alzheimer's disease. Patent Summary: "Spirocyclic dihydro-thiazine and dihydro-oxazine bace inhibitors, and compositions and uses thereof". The compounds are provided having a structure according to formula (i): wherein a 1, a 2, a 3, y, r 1, r 2, r 3, r 4, r 5, r 6, m, n and p are defined herein. Still provided are pharmaceutical compositions including the compounds provided and methods of making and using the compounds and compositions thus provided, for example, in the treatment and prevention of various disorders, such as alzheimer's disease.abstract compounds are provided having a structure according to formula i: i wherein a1, a2, a3, y, r1, r2, r3, r4, r5, r6, m, n and p are defined herein. further provided are pharmaceutical compositions including the compounds provided and methods of making and using the compounds and compositions as provided, e.g., in the treatment and prevention of various disorders, such as alzheimer’s disease. tradução do resumo resumo patente de invenção: “inibidores de bace de di-hidro-tiazina e di-hidro-oxazina espirocíclicos, e composições e usos dos mesmos”. os compostos são fornecidos tendo uma estrutura de acordo com a fórmula (i): em que a1, a2, a3, y, r1, r2, r3, r4, r5, r6, m, n e p são definidos aqui. ainda fornecidas são composições farmacêuticas incluindo os compostos fornecidos e métodos de fazer e usar os compostos e composições assim fornecidos, por exemplo, no tratamento e prevenção de vários distúrbios, tais como doença de alzheimer.
