РОСЕНДАЛ Рамон (NL),РОС Анна (NL),РАДОШЕВИЧ Катарина (NL)
申请号：
RU2014140168
公开号：
RU2014140168A
申请日:
2013.03.05
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A method for the induction of cross-protection against different influenza strains which comprise at least one heterologous strain compared with strains, HA and NA of which are present in the influenza vaccine, comprising administering an influenza vaccine comprising HA and NA of at least three virus strains flu, where the vaccine is virosomal influenza vaccine that does not contain an adjuvant, and which is administered intramuscularly to a subject at least three times within one year, and which are not administered to a subject HA and NA from at least one heterologous shtamma.2. A method of cross-protection induction from at least one heterosubtypic strain compared with the influenza strains, antigens of which are present in the influenza vaccine, comprising: administering an influenza vaccine comprising HA and NA, wherein the vaccine is virosomal influenza vaccine that does not contain an adjuvant, and that intramuscularly administered at least three times within one years.3. A method according to any one of claims. 1 or 2, wherein the vaccine is administered with an interval between administrations of at least one week, preferably at intervals of about three to eight nedel.4. A method according to any one of claims. 1-3, where the second dose of vaccine administered to the subject through a period from 1 week to 8 weeks after the first dose and the third dose of vaccine administered to the subject through the period from 3 weeks to 26 weeks after the second dozy.5. A method according to any one of claims. 1-4, where the second dose of vaccine administered to the subject after about one month after the first dose and the third dose of vaccine administered to the subject after about one month after the second dozy.6. A method according to any one of claims. 1-5, wherein the vaccine comprises HA and NA and1. Способ индукции перекрестной защиты от различных штаммов гриппа, которые включают по меньшей мере один гетерологичный штамм по сравнению со штаммами, HA и N
