Synthesis of (S)-2-acetamido-3-(4-hydroxy-3-(3-methylbut-2-enyl) phenyl) propanoic acid derivatives

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专利权人:

King Fahd University of Petroleum and Minerals

发明人:

Muhammad Mansha,Yasir Abbas,Nisar Ullah

申请号：

US14918658

公开号：

US09688611B2

申请日:

2015.10.21

申请国别(地区):

US

年份:

2017

代理人:

摘要：

A method for producing a compound of formula (I) or a pharmaceutically acceptable salt, solvate, tautomer or stereoisomer, such as compound 1 and compound 2 is disclosed. The method proceeds through an O-allylated tyrosine-based compound, such as compound 3 and preferably comprises [3,3] sigmatropic Claisen rearrangement and olefin cross metathesis reactions. In addition, a pharmaceutical composition comprising a compound of formula (I) a tumor necrosis factor (TNF) related apoptosis inducing ligand (TRAIL) and a pharmaceutically acceptable carrier or excipient is disclosed.

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