Midatech Limited;University College Cardiff Consultants Limited;Nanopass Technologies LTD.;Leiden University Medical Center;Institut National De La Sante et de la Recherche Medicale
发明人:
Martina McAteer,Colin Mark Dayan,James Caradoc Birchall
申请号：
US15561935
公开号：
US20180177891A1
申请日:
2016.04.08
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides a nano particle comprising: a core comprising metal atoms； a corona comprising a plurality of ligands covalently linked to the core, wherein said plurality of ligands comprises: at least one carbohydrate ligand； at least one glutathione ligand； and at least one autoantigen peptide ligand. Also provided are compositions and vaccines comprising the nanoparticles, methods for producing the nanoparticles and medical uses of the nanoparticles, including for antigen specific imunotherapy of an autoimmune disease, such as diabetes mellitus type 1, in a mammalian subject.
