The invention provides compositions comprising one or more expression vectorsencoding an antigen recognized by CD4+ helper T cells and an antigenrecognized by CD8+cytotoxic T cells (CTL), and in particular, a tumor-specific, tumor-associated, or cell-relatedantigen. In addition, the compositions preferably comprise an expressionvector encodinginterferon gamma. Specifically, the antigens recognized by CD4+ helper T cellsinclude, forexample, cancer/testis antigens such as NY-ESO-1, and antigens recognized byCD8-cytotoxicT cell (CTL), in particular, the tumor-specific, tumor-associated, or cell-related antigens include,for example, HER-2/neu and cancer/testis antigens such as NY-ESO-1, MAGE, andSAGE.
