COMPOSITIONS AND THERAPEUTIC USES OF HEPES AND DERIVATIVES IN THE TREATMENT OF PAIN ASSOCIATED WITH CANCERS AND SIDE-EFFECTS INCLUDING POST-CHEMOTHERAPY COGNITIVE IMPAIRMENT ARE DISCLOSED HEREIN. HEPES IS ALSO USED TO TREAT NEURODEGENERATIVE AND NEUROLOGICAL DISEASES, DEMYELIZATION INJURIES, AND SIDE-EFFECTS AND WITHDRAWAL SYMPTOMS ASSOCIATED WITH BENZODIAZEPINES, ANTI-DEPRESSANTS, AND OTHER NEUROLOGICAL AGENTS.