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Pharmaceutical compositions comprising hydromorphone and naloxone
专利权人:
发明人:
VARGAS RINCON RICARDO ALBERTO
申请号:
IN3717/DELNP/2015
公开号:
IN2015DN03717A
申请日:
2015.04.30
申请国别(地区):
IN
年份:
2015
代理人:
摘要:
Disclosed is a prolonged release pharmaceutical dosage form comprising a plurality of coated beads , each comprising a granule, a first layer coated on the granule comprising hydromorphone , naloxone , an antioxidant compound and a chelatmg compound and a second layer coated on the first layer comprising a prolonged release agent. The dosage form has improved stability and dissolution properties. Also disclosed is the use of a combination of an antioxidant , such as sodium metabisulfite , and a chelatmg agent , such as EDTA , to improve the stability and/or dissolution properties of a prolonged release dosage form comprising hydromorphone and naloxone.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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