Replaceable head toothbrush providing controlled brushing pressure

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专利权人:

BRISTOL-MYERS SQUIBB CO.

发明人:

申请号：

BE2011C041

公开号：

BE2011C041I2

申请日:

2011.11.10

申请国别(地区):

BE

年份:

2020

代理人:

摘要：

The present invention provides soluble CTLA4 mutant molecules which bind with greater avidity to the CD80 and/or CD86 antigen than wild type CTLA4 or non-mutated CTLA4Ig. The soluble CTLA4 molecules have a first amino acid sequence comprising the extracellular domain of CTLA4, where certain amino acid residues within the S25-R33 region and M97-G107 region are mutated. The mutant molecules of the invention may also include a second amino acid sequence which increases the solubility of the mutant molecule.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/