DETAILED DESCRIPTION OF THE INVENTION An agonist composition of TrkB or TrkC that is administered to an individual suffering from an otic disease or condition by direct application to a targeted otic structure and through perfusion to said structure. And compositions and methods for the treatment of otic diseases or conditions using the formulations are disclosed. [Selection] Figure 1本明細書には、標的とされた耳の構造への直接の適用により、及び前記構造への灌流を介して、耳の疾患又は疾病に悩む個体へと投与されるTrkB又はTrkCのアゴニスト組成物及び製剤を用いる、耳の疾患又は疾病の処置のための組成物及び方法が開示される。【選択図】図1