MATTHEW LLOYD,TIMOTHY WOODMAN,MAKSIMS JEVGLEVSKIS,MICHAEL THREADGILL,GUAT LEE
申请号：
US15115851
公开号：
US20170176436A1
申请日:
2015.02.02
申请国别(地区):
US
年份:
2017
代理人:
摘要：
A method of measuring α-methylacyl-CoA racemase (AMACR) activity in a sample is described comprising the steps of: (i) providing a sample (ii) contacting said sample with a substrate compound that undergoes elimination of hydrogen and a leaving group catalysed by said AMACR to produce a product compound having an additional carbon-carbon double bond and (iii) measuring the amount of said leaving group and/or of said product compound and/or of unreacted substrate compound. Also provided are methods of diagnosis and medical imaging, in particular for use in diagnosing prostate cancer. Also provided are substrate compounds of Formula 1 for use in the methods described herein.
