ALLEN-HOFFMANN, LYNN,PICKART, MICHAEL A.,SCHLOSSER, SANDRA J.
申请号：
AT06003693
公开号：
AT550439T
申请日:
1999.07.12
申请国别(地区):
AT
年份:
2012
代理人:
摘要：
A spontaneously immortalized human keratinocyte cell line is disclosed. In a preferred embodiment, this cell line is ATCC 12191. In another embodiment of the invention, a method of assaying the effect of a test tumor cell modulation agent is disclosed. The method comprises the steps of obtaining a human stratified squamous epithelial cell culture, wherein the culture comprises human malignant squamous epithelial cells and spontaneously immortalized human keratinocytes, wherein the culture forms a reconstituted epidermis. One then treats the epidermis with a test tumor cell modulation agent and evaluates the growth of the malignant cells within the epidermis.
