The systems and methods disclosed herein concern the modulation of autonomic function and/or biological processes. The systems and methods are useful for treating or preventing diseases, disorders, or conditions having an autonomic tone or function component. Certain embodiments relate to a system that receives signals from a biological entity to modulate the biological processes of that entity through the modulation of light or other relevant parameters. Alternative embodiments involve the use of sensors to obtain data regarding an individual and using that data to specify a lighting environment. Further embodiments involve systems that collect and transmit sensor data to a controller that designates a selected lighting environment that is useful for modulating, treating or preventing a physiological or pathological state. Additional embodiments utilize a controller that transmits a signal to a driver that specifies a particular lighting environment for an individual in need of modulation, treatment or prevention.