A protective cover or patch for covering and securing a catheter at the site of insertion of the needle into the patients skin includes a single piece cover having a portion disposed about the perimeter of the patch bearing an adhesive coating and adapted for securement to a patients skin in the vicinity of the site of insertion, a bulbous chamber disposed inwardly of the perimeter portion, and a connecting portion disposed between the first portion and the chamber portion, the chamber portion defining a chamber for receiving one end of the catheter and extending substantially diametrically from one side of the perimeter to the other, and resilient tubing engagement elements positioned on opposite sides of the chamber. The chamber of the protective patch includes a roof portion raised above the plane defined by said perimeter of the patch.
