The present invention concerns derivatives of heteroarylsulfonamides, notably as blockers of Kv potassium channels, and more particularly of channels Kv1.5, Kv4.3 or Kv11.1, their application in clinical therapy and their preparation methods.These compounds correspond to the following general formula I:where R1 represents one or more substituents of the phenyl core X such as: hydrogen, halogen, trifluoromethyl, trifluoromethoxy, linear or branched C1-C4 alkyl, or linear or branched C1-C4 alkoxy, A represents oxygen or sulphur, B represents nitrogen when n=1 or 2 and D represents -C(=O)-, or B represents CH when n=0 and D represents -CH2O- or when n=1 and D represents -O-, R2 represents a hydrogen, a methyl, a fluorine or chlorine atom or a methoxy, HetAr represents a pyridyl or quinolyl group, possibly substituted by a group such as a linear or branched C1-C4 alkyl, a linear or branched C1-C4 alkoxy, a halogen, or a trifluoromethyl, and to their pharmaceutically acceptable salts.本發明係有關於雜芳基磺醯胺之衍生物,特別是作為Kv鉀通道且更特別係Kv1.5、Kv4.3或Kv11.1通道之阻斷劑,其於臨床治療之應用與其製備方法。此等化合物係相對應於下列通式I:其中,R1表示苯基核X之一或多個取代基,諸如:氫、鹵素)、三氟甲基、三氟甲氧基、線性或分支之C1-C4烷基,或線性或分支之C1-C4烷氧基,A表示氧或硫,當n=1或2且D表示-C(=O)-時,B表示氮,或當n=0且D表示-CH2O-或當n=1且D表示-O-時,B表示CH,R2表示氫、甲基、氟或氯原子,或甲氧基,HetAr表示一吡啶基或喹啉基基團,可能以諸如線性或分支之C1-C4烷基、線性或分支之C1-C4烷氧基、鹵素,或三氟甲基之一基團取代,與其藥學上可接受之鹽。
