Alan Martin Birch,Roger John Butlin,Leonie Campbell,Clive Green,Andrew Leach,Michael James Waring,Paul Michael Murray,Per Olof Ryberg
申请号：
US12818187
公开号：
US08188092B2
申请日:
2010.06.18
申请国别(地区):
US
年份:
2012
代理人:
摘要：
DGAT-1 inhibitor compounds of formula (I), pharmaceutically-acceptable salts and pro-drugs thereof are described, together with pharmaceutical compositions, processes for making them and their use in treating, for example, obesitywherein, for example, r is 0 or 1 and X1 is linear (1-3C)alkyl q is 0 or 1 and X2 is fluoro, chloro or (1-3C)alkyl Y1 is selected from fluoro, chloro, bromo, cyano, (1-3C)alkyl and (1-2C)alkoxy n is 0, 1 or 2 and Y2 is fluoro, chloro or (1-3C)alkyl p is 0, 1 or 2 and Y3 is (1-3C)alkyl or forms a (3-5C)cycloalkyl ring Z is carboxy or —CONHSO2Me or —CONRbRc wherein Rb and Rc are independently selected, for example, from hydrogen and (1-4C)alkyl or Rb and Rc are linked so as to form a morpholine ring or a (4-6C)heterocyclic ring and when Z is —CONRbRc the Rb and Rc groups may be optionally substituted by carboxy.
