The new hybrid X Heucherella plant named ‘Pumpkin Spice’ with deeply-incised, palmately lobed foliage of variable coloration starting in the spring as bright orange with deep blood-red veins, transitioning to deep burgundy surrounding veins during flowering and burnt orange between the veins and in winter becoming deep green with black mahogany surrounding veins. The new plant begins flowering in late spring with a near white flowers on dark red stems. ‘Pumpkin Spice’ is suitable for landscaping en masse, as a specimen accent or as a container plant.