Provided is an aptamer having a binding activity to NGF (nerve growth factor) and a better quality; the aptamer bound NGF satisfying the follows: (1)containing a sequence “UGAAARAAACC” represented in SEQ ID NO.64 or “CGAAMRAAACU” represented in SEQ ID NO.65; (2)the length of the base being equal to or less than 73.本發明提供一種對NGF具有結合活性且更優質的適體。該結合至NGF之適體係滿足下列(1)及(2):(1)包含UGAAARAAACC(序列編號64)或CGAAMRAAACU(序列編號65)所示之序列。(2)鹼基長度為73個以下者。