A hand-held instrument is provided for smoke evacuation at a tissue site. The instrument may include a housing sized for hand-held use and defining at least a portion of an internal volume of the instrument. An inlet port and an outlet port are provided for gas passage in to and out of the internal volume, wherein an impeller is disposed within the internal volume between the inlet port and the outlet port. In some embodiments, an on-board motor may be disposed within the internal volume to rotate the impeller and induce gas flow in to the inlet port and out of the outlet port. A filter may be located at the outlet port for filtering gas flowing out of the outlet port. In some embodiments, an energy emission component (e.g., an electrosurgical electrode) may be integrated into the hand-held instrument. Additionally, some embodiments may include one or a plurality of light emitters for emitting light in a direction distal to a distal end of the hand-held instrument.