您的位置: 首页 > 农业专利 > 详情页

COMPOSITIONS AND METHODS FOR TREATING Gaucher Disease
专利权人:
ШАЙР ХЬЮМАН ДЖЕНЕТИК ТЕРАПИЗ (US)
发明人:
ДЭНИЕЛ Питер Ф. (US),ХАРТЛЕЙН Майкл У. (US)
申请号:
RU2012107103/15
公开号:
RU2012107103A
申请日:
2010.07.28
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A method of treating a subject with Gaucher disease, comprising carrying out glucocerebrosidase enzyme replacement therapy by intravenous infusion to a subject for a period of time less than 2 hours for therapeutic purposes. The method according to claim 1, characterized in that the introduction of glucocerebrosidase replacement enzyme therapy is carried out for 90 minutes or less. The method according to claim 1, characterized in that the administration of glucocerebrosidase enzyme replacement therapy is carried out for 60 minutes or less. The method according to claim 1, characterized in that it further comprises administering a second preparation for glucocerebrosidase enzyme replacement therapy by intravenous infusion to a subject over a period of time of less than 2 hours. The method according to claim 1, characterized in that the preparation for glucocerebrosidase enzyme replacement therapy is selected from the group consisting of velaglucerase, imiglucerase and uplyso. The method according to claim 1, characterized in that the administration of glucocerebrosidase enzyme replacement therapy is carried out in a dosage of from 15 to 60 units / kg. A method for identifying a subject suitable for treatment with glucocerebrosidase enzyme replacement therapy, comprising: determining the presence of neutralizing antibodies to a preparation for glucocerebrosidase enzyme replacement therapy in a sample obtained from a subject for measuring the level of antibodies against a therapeutic drug, the subject currently receiving the first glucocerebrosidase replacement enzyme therapy or previously received the first glucocerebrosidase enzyme replacement ter apia, equation1. Способ лечения субъекта с болезнью Гоше, включающий проведение глюкоцереброзидазной заместительной ферментной терапии путем внутривенных инфузий субъекту в течение периода времени менее 2 ч в лечебных целях.2. Способ согласно п.1, отличающийся тем, что введение глюкоцереброзидазной заместительной фермен
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充