SERUM AMYLOID P DERIVATIVES AND THEIR PREPARATION AND USE

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专利权人:

INC.;PROMEDIOR

发明人:

WILLETT, W.SCOTT,CAIMI,RICHARD J.

申请号：

MYPI2011005861

公开号：

MY158761A

申请日:

2010.06.04

申请国别(地区):

MY

年份:

2016

代理人:

摘要：

ONE ASPECT OF THE PRESENT INVENTION RELATES TO THE SURPRISING DISCOVERY THAT MODIFICATION OF A GLYCAN STRUCTURE ON A HUMAN SAP POLYPEPTIDE CAN INCREASE THE BIOLOGICAL ACTIVITY OF THE SAP POLYPEPTIDE RELATIVE TO A CORRESPONDING SAMPLE OF WILD-TYPE SAP ISOLATED FROM HUMAN SERUM. THE DISCLOSURE PROVIDES BOTH VARIANT HUMAN SAP POLYPEPTIDES AND METHODS FOR MAKING THE SAME. IN PARTICULAR, THE PRESENT INVENTION PROVIDES METHODS AND COMPOSITIONS FOR IN VITRO AND IN VIVO ADDITION, DELETION, OR MODIFICATION OF SUGAR RESIDUES TO PRODUCE SAP POLYPEPTIDES, SUCH AS A HUMAN SAP POLYPEPTIDE, HAVING A DESIRED GLYCOSYLATION PATTERN.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/