PROBLEM TO BE SOLVED: To provide a phamaceutical composition (an anti-inflammatory drug for inflammatory bowel disease) which is effective for improving inflammatory bowel disease whose treatment has been difficult heretofore, particularly, ulcerative colitis, or for maintaining its batement conditions.SOLUTION: The anti-inflammatory drug for inflammatory bowel disease includes a water-soluble vitamin E derivative represented by general formula (I) or its pharmalogically allowable salt as an active constituent: [wherein, R1 and R2 are same or different, and denote a hydrogen atom or a 1 to 3C lower alkyl group R3 and R5 are different, and denote a hydrogen atom or an S-bonded SH compound or its ester and R4 denotes a hydroxyl group, N-substituted amino acid or its ester or amine].COPYRIGHT: (C)2013,JPO&INPIT【課題】従来治療が困難であった炎症性腸疾患、特に潰瘍性大腸炎の改善または緩解状態を維持するために有効な医薬組成物(抗炎症性腸疾患剤)を提供する。【解決手段】下記一般式(I)で示される水溶性ビタミンE誘導体またはその薬理学的に許容される塩を有効成分とする、抗炎症性腸疾患剤:〔式中、R1およびR2は、同一または異なって、水素原子または炭素数1~3の低級アルキル基を示し、R3およびR5は、異なって、水素原子であるか、またはS結合したSH化合物若しくはそのエステルを示し、R4は水酸基、N-置換アミノ酸若しくはそのエステル、またはアミンを示す〕【選択図】なし
