DUKSUNG WOMEN'S UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
LEE, JAE IN,이재인,LEE, HEE JU,이희주
申请号：
KR1020170050939
公开号：
KR1019003740000B1
申请日:
2017.04.20
申请国别(地区):
KR
年份:
2018
代理人:
摘要：
In an embodiment of the present invention, provided is a method for preparing a 5-chlorophenyl-2-furancarbothioamide-based compound, the method comprising: a first step of preparing 5-chlorophenyl-2-furoic acid by making benzene diazonium chloride compound, prepared by making aniline chloride and sodium nitrite react to each other, react with 2-furoic acid； a second step of preparing a 2-pyridyl ester compound by treating 5-chlorophenyl-2-furoic acid, prepared in the first step, with di-2-pyridyl carbonate (2-DPC) and preparing 5-(chlorophenyl)-2-furancarboamide by adding amine to the 2-pyridyl ester compound； and a third step of treating 5-chlorophenyl-2-furancarboamide, prepared in the second step, with Lawesson′s reagent.본 발명의 일 실시예는, 염화아닐린(chloroanilines)과 아질산 나트륨을 반응시켜 제조된 염화벤젠디아조늄 화합물을 2-퓨로산(2-furoic acid)과 반응시켜 5-(클로로페닐)-2-퓨로산을 제조하는 제1 단계, 상기 제1 단계에서 제조된 5-(클로로페닐)-2-퓨로산을 디-2-피리딜 카보네이트(2-DPC)로 처리하여 2-피리딜 에스테르 화합물을 제조하고, 여기에 아민을 첨가하여 5-(클로로페닐)-2-퓨란카보아미드를 제조하는 제2 단계 및 상기 제2 단계에서 제조된 5-(클로로페닐)-2-퓨란카보아미드를 로손 시약(Lawesson's reagent)으로 처리하는 제3 단계를 포함하는, 5-클로로페닐-2-퓨란카보티오아미드계 화합물의 제조방법을 제공한다.
