ANDRIES, KOENRAAD,KOUL, ANIL,GUILLEMONT, JEROME,PASQUIER, ELISABETH,LANSOIS, DAVID
申请号：
ES06763532
公开号：
ES2452736T3
申请日:
2006.06.06
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Use of a compound for the preparation of a medicament for the treatment of a bacterial infection caused by staphylococci, enterococci or streptococci, said compound being a compound of formula ** Formula * + a pharmaceutically acceptable acid or basic addition salt thereof, a form stereochemically isomer thereof or an N-oxide form thereof, in which: R 1 is hydrogen, halo, C 1-6 polyhaloalkyl, C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 alkyloxy, Ar or Het； p is an integer equal to 1 or 2； R2 is C1-6 alkyloxy, C1-6 alkyloxy C1-6 alkyloxy or C1-6 alkylthio； R3 is C1-6 alkyl, Ar, Het or Het1； R4 and R5 are each independently hydrogen, C1-6 alkyl or benzyl； or R4 and R5 together and including the N to which they are attached can form a radical selected from the group of pyrrolidinyl, 2-pyrrolinyl, 3-pyrrolinyl, pyrrolyl, imidazolidinyl, pyrazolidinyl, 2-imidazolinyl, 2-pyrazolinyl, imidazolyl, pyrazolyl, triazolyl, piperidinyl, pyridinyl, piperazinyl, pyridacinyl, pyrimidinyl, pyrazinyl, triacinyl, morpholinyl and thiomorpholinyl, each of said rings may be optionally substituted with C1-6 alkyl, halo, C1-6 polyhaloalkyl, hydroxy, hydroxy C1-6 alkyl, alkoxy C 1-6, amino, mono or di (C 1-6 alkyl) amino, C 1-6 alkylthio, C 1-6 alkyloxyC 1-6 alkyl, C 1-6 alkylthioC 1-6 alkyl or pyrimidinyl； R 6 is hydrogen, halo, C 1-6 polyhaloalkyl, C 1-6 alkyl, C 1-6 alkyloxy, C 1-6 alkylthio； or two neighboring R6 radicals can be taken together to form a bivalent radical of the formula -CH>； = CHCH>； = CH-； r is an integer equal to 1 or 2； R7 is hydrogen, C1-6 alkyl, Ar, Het or Het1； Ar is a homocycle selected from the group of phenyl, naphthyl, acenaphthyl, 1,2-dihydro-acenaphthyl, tetrahydronaphthyl, each homocycle being optionally substituted with 1, 2 or 3 substituents, each substituent being independently selected from among the hydroxy group, halo, cyano, nitro, amino, mono odi (C 1-6 alkyl) amino, C 1-6 alkyl, C 1-6 polyhaloalkyl, C 1-6 hydroxyalkyl, C 1-6 alkyloxy, C 1-6 polyhaloa
