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Oral preparation containing specific organic acid and method for improving dissolution and chemical stability of oral preparation
专利权人:
東レ株式会社
发明人:
太田 琴恵,皆神 賢,徳満 宏之
申请号:
JP2009515239
公开号:
JP5343845B2
申请日:
2008.05.20
申请国别(地区):
JP
年份:
2013
代理人:
摘要:
A chemically stable oral preparation with an excellent dissolution property comprising as an effective ingredient a specific morphinan derivative or a pharmaceutically acceptable acid addition salt thereof is disclosed. The oral preparation according to the present invention comprises a specific morphinan derivative or a pharmaceutically acceptable acid addition salt thereof as an effective ingredient and an organic acid, wherein 1 g of said organic acid requires not less than 30 mL of water to dissolve in at 20°C. The method for improving dissolution property and chemical stability of an oral preparation according to the present invention comprises incorporating an organic acid in the oral preparation comprising as an effective ingredient a specific morphinan derivative or a pharmaceutically acceptable acid addition salt thereof, wherein 1 g of said organic acid requires not less than 30 mL of water to dissolve in at 20°C.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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