MODIFIED MONOCYTES/MACROPHAGE EXPRESSING CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF

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专利权人:

发明人:

GILL SAAR,KLICHINSKY MICHAEL,JUNE CARL H

申请号：

IN201817003010

公开号：

IN201817003010A

申请日:

2018.01.25

申请国别(地区):

IN

年份:

2018

代理人:

摘要：

The present invention includes methods and compositions for treating cancer whether a solid tumor or a hematologic malignancy. By expressing a chimeric antigen receptor in a monocyte macrophage or dendritic cell the modified cell is recruited to the tumor microenvironment where it acts as a potent immune effector by infiltrating the tumor and killing the target cells. One aspect includes a modified cell and pharmaceutical compositions comprising the modified cell for adoptive cell therapy and treating a disease or condition associated with immunosuppression.

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中国工程科技知识中心

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http://www.ckcest.cn/home/