INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 15 November 2018 (15.11.2018) WIPO I PCT omit °nolo His mom ono iflo oimIE (10) International Publication Number WO 2018/208769 Al N GC O 00 O 1-1 R4 R5 Y . N—N X 6 R (51) International Patent Classification: A61K 31/439 (2006.01) A61P 31/04 (2006.01) C07D 471/08 (2006.01) (21) International Application Number: PCT/US2018/031593 (22) International Filing Date: 08 May 2018 (08.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/502,867 08 May 2017 (08.05.2017) US (71) Applicant: ENTASIS THERAPEUTICS, INC. [US/US]； 35 Gatehouse Drive, Waltham, MA 02451 (US). (72) Inventors: COMITA-PREVOIR, Janelle； 11 Prospect Street, Northborough, MA 01532 (US). DU- RAND-REVILLE, Thomas, Francois； 34 Birch Hill Road, Belmont, MA 02478 (US). GULER, Satenig； 35 Gatehouse Drive, Waltham, MA 02451 (US). ROMERO, Jan； 8 Langley Road, Arlington, MA 02474 (US). SYLVESTER, Mark； 35 Gatehouse Drive, Waltham, MA 02451 (US). TOMMASI, Ruben； 16 Salamander Lane, Stow, MA 01775 (US). VELEZ-VEGA, Camilo； 35 Gate- house Drive, Waltham, MA 02451 (US). WU, Xiaoyun； 3 Hundreds Road, Westborough, MA 01581 (US). ZHANG, Jing； 11 Run Brook Circle, Sudbury, MA 01776 (US). (74) Agent: DAVIS, Steven, G. et al.； McCarter & English, LLP, 265 Franklin Street, Boston, MA 02110 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, S
