Fundación Centro Nacional de Investigaciones Oncológicas Carlos III
发明人:
PASTOR FERNANDEZ, Joaquín,FERNANDEZ-CAPETILLO RUIZ, Oscar,MARTINEZ GONZALEZ, Sonia,BLANCO APARICIO, Carmen,RICO FERREIRA, María del Rosario,TOLEDO LAZARO, Luis Ignacio,RODRIGUEZ ARISTEGUI, Sonsoles,MU
申请号：
ES14716910
公开号：
ES2670674T3
申请日:
2014.03.14
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A chemical entity selected from the compounds of Formula (I) ** Formula ** in which R 1 represents a bicyclic heteroaryl selected from the group consisting of indazolyl, indolyl, benzimidazolyl and pyrrolopyridinyl； R2 is selected from NR3SO2R3, alkyl and cycloalkyl； wherein R3 is independently selected at each occurrence from H, alkyl optionally substituted with 1, 2 or 3 halogen atoms, cycloalkyl optionally substituted with 1, 2 or 3 halogen atoms and heterocycloalkyl optionally substituted with 1, 2 or 3 atoms of halogen； and m is 1 or 2； alkyl is a linear saturated hydrocarbon having up to 10 carbon atoms (C1-C10) or a branched saturated hydrocarbon of between 3 and 10 carbon atoms (C3-C10)； cycloalkyl is a monocyclic or bicyclic saturated C3-C10 hydrocarbon, which may optionally be condensed with an aryl group； or cycloalkyl is adamantyl； heterocycloalkyl is a saturated monocyclic or bicyclic ring attached to C or attached to 3-10 N members, containing 1, 2, 3 or 4 ring heteroatoms independently selected from N, S and O, in which an atom of N or S in the ring can be substituted with oxygen to form an N-oxide, sulfoxide or sulfone group； aryl is phenyl, biphenyl or naphthyl； and heteroaryl is a monocyclic, bicyclic or tricyclic aromatic ring of 5, 6, 9 or 10, 12, 13 or 14 members, which may contain 1, 2, 3 or 4 ring heteroatoms independently selected from N, S and O； wherein R2 represents alkyl or cycloalkyl, said alkyl or cycloalkyl is substituted with at least one substituent selected from (NR4) nSO2R4, wherein n is 0 or 1, OH and CN； and said alkyl or cycloalkyl is optionally further substituted with 1 or 2 substituents independently selected from halogen, CN, COOR4, CF3, C1-C6 alkyl optionally substituted with 1, 2 or 3 halogen atoms, cycloalkyl optionally substituted with 1, 2 or 3 halogen atoms and O-C1-C6 alkyl optionally substituted with 1, 2 or 3 halogen atoms, or two substituents can be taken in a single atom together with the atom to which they are fi
