CALS, Joseph Maria Gerardus Barbara,NABUURS, Sander Bernardus
申请号：
TN2016000224
公开号：
TN2016000224A1
申请日:
2014.12.03
申请国别(地区):
TN
年份:
2017
代理人:
摘要：
The present invention relates to compounds according to Formula I: Wherein: A<；sub>；11<；/sub>； - A<；sub>；14<；/sub>； are N or CR<；sub>；11<；/sub>；, CR<；sub>；12<；/sub>；, CR<；sub>；13<；/sub>；, CR<；sub>；14<；/sub>；, respectively, with the proviso that no more than two of the four positions A can be simultaneously N； R<；sub>；1<；/sub>； is C(l-6)alkyl, C(3-6)cycloalkyl, C{3-6)cycloalkylC(l -3)alkyl, {di)C(l-6)alkylamino, {di)C(3-6)cycloalkylamino or {di){C(3-6)cycloalkylC(l -3)alkyl)amino, with all carbon atoms of alkyl groups optionally substituted with one or more F and ail carbon atoms of cycloalkyl groups optionally substituted with one or more For methyl； R<；sub>；2<；/sub>； and R<；sub>；3<；/sub>； are independently H, F, methyl, ethyl, hydroxy, methoxy or R<；sub>；2<；/sub>； and R<；sub>；3<；/sub>； together is carbonyl, ail alkyl groups, if present, optionally being substituted with one or more F； R<；sub>；4<；/sub>； is H or C(l-6)alkyl； R<；sub>；5<；/sub>； is H, hydroxyethyl, methoxyethyl, C(l-6)alkyl, C{6-10)aryl, C(6-10)arylC(l-3)alkyl, C(l -9)heteroaryl, C{l-9)heteroarylC(l-3)alkyl, C(3-6)cycloalkyl, C(3-6)cycloalkylC(l -3)alkyl, C(2-S)heterocycloalkyl or C(2-S)heterocycloalkylC(l-3)alkyl, all groups optionally substituted with one or more F, Cl, C{l-2)alkyl, C{l-2)alkoxy or cyano； the sulfonyl group with R<；sub>；1<；/sub>； is represented by one of R<；sub>；7<；/sub>；, R<；sub>；8<；/sub>； or R<；sub>；9<；/sub>；； the remaining R6-RH are independently H, halogen, C{l- 3)alkoxy, (di)C(l-3)alkylamino or C(l-6)alkyl, all of the alkyl groups optionally being substituted with one or more F； and Ri5 and Ri6 are independently H, C{l-6)alkyl, C(3-6)cycloalkyl, C(3-6)cycloalkylC{l-3)alkyl, C(6-10)aryl, C(6-10)arylC(l-3)alkyl, C{l-9)heteroaryl, C{l-9)heteroarylC(l-3)alkyl, C{2-S)heterocycloalkyl or C(2-S)heterocycloalkylC(l-3)alkyl, all groups optionally substit
