UNIVERSITY OF HOUSTON;ST. LUKE'S EPISCOPAL HOSPITAL
发明人:
HOR, Pei-Herng,MUTHUPILLAI, Raja,ZHANG, Jiming
申请号：
USUS2013/039749
公开号：
WO2013/166504A2
申请日:
2013.05.06
申请国别(地区):
US
年份:
2013
代理人:
摘要：
In some embodiments, the present disclosure pertains to a method of delivery of an active agent to a target tissue, in a subject in need thereof. Such a method may comprise the step of identifying the target tissue in the subject. In some embodiments, the method further comprises positioning a high intensity focused ultrasound transducer to enable delivery of ultrasound energy to the target tissue. Such a method may also comprise energizing the high intensity focused ultrasound transducer to thermally stimulate the target tissue； imaging at least a portion of the target tissue that includes the volume of the target tissue being thermally stimulated； and discontinuing delivery of ultrasound energy when said target tissue achieves a pre-determined set temperature or temperature profile. Further, such a method may comprise administering the active agent to the subject under the conditions of thermal stimulation. In some embodiments, the thermal stimulation may induce a temperature dependent large increase of blood perfusion to the target tissue. In another embodiment, the present disclosure relates to a method of treating a tumor in a subject in need thereof comprising the steps of administering a therapeutic agent to the subject； and providing thermal stimulation to the tumor. In yet, another embodiment, there is provided a method for increasing the efficacy of a therapeutic agent in a target tissue, in a subject in need thereof, comprising the steps of administering a therapeutic agent to the subject； and providing thermal stimulation to the target tissue.Dans certains modes de réalisation, la présente invention concerne un procédé d'administration d'un agent actif à un tissu cible, chez un sujet en ayant besoin. Un tel procédé peut comprendre l'étape d'identification du tissu cible dans le sujet. Dans certains modes de réalisation, le procédé comprend en outre le positionnement d'un transducteur ultrasonore focalisé de haute intensité pour permettre la distribution
