Markus Stoffel,Muthiah Manoharan,Kallanthottathil G Rajeev
申请号：
US12714863
公开号：
US08541385B2
申请日:
2010.03.01
申请国别(地区):
US
年份:
2013
代理人:
摘要：
This invention relates generally to chemically modified oligonuceotides useful for modulating expression of microRNAs and pre-microRNAs. More particularly, the invention relates to single stranded chemically modified oligonuceotides for inhibiting microRNA and pre-microRNA expression and to methods of making and using the modified oligonucleotides. Also included in the invention are compositions and methods for silencing microRNAs in the central nervous system.
