Mark T. Bilodeau,Melissa Egbertson,Ahren Green,John C. Hartnett,Yiwei Li
申请号：
US13499844
公开号：
US20120196894A1
申请日:
2010.09.28
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to compositions and methods that modulate at least one TRP family member. Specifically, the present invention relates to novel TRPA1 antagonists and their use in the treatment of pain such as chronic inflammatory and neuropathic pain. Compounds that can modulate one or more TRPA1 functions are useful in many aspects including, but not limited to, maintaining calcium homeostasis maintaining sodium homeostasis modulating intracellular calcium levels modulating membrane polarization (membrane potential) modulating cation levels and/or treating or preventing diseases, disorders, or conditions associated with calcium homeostasis, sodium homeostasis, calcium or sodium dyshomeostasis, or membrane polarization/hyperpolarization (including hypo and hyperexcitability), and/or treating or preventing diseases, disorders, or conditions associated with regulation or misregulation of TRPA1 expression or function. The present invention further relates to methods and compositions that antagonize both a function of TRPA1 and a function of one or more additional TRP channels.
