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MONOCLONAL ANTIGEN-BINDING PROTEINS TO INTRACELLULAR ONCOGENE PRODUCTS
专利权人:
发明人:
David A. SCHEINBERG,Tao DAO,Cheng LIU
申请号:
US15710384
公开号:
US20180134804A1
申请日:
2017.09.20
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Antigen binding proteins specific for an HLA-A2 restricted Ras peptide are disclosed. The antigen binding proteins encompass antibodies in a variety of forms, including full-length antibodies, substantially intact antibodies, Fab fragments, F(ab′)2 fragments, and single chain Fv fragments. Fusion proteins, such as scFv fusions with immunoglobulin or T-cell receptor domains, and bispecific antibodies incorporating the specificity of the antigen binding region for each peptide are also contemplated by the disclosure. Furthermore, immunoconjugates may include antibodies to which is linked a radioisotope, fluorescent or other detectable marker, cytotoxin, or other molecule are also encompassed by the disclosure. Among other things, immunoconjugates can be used for delivery of an agent to elicit a therapeutic effect or to facilitate an immune effector function.
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