Disclosed herein is a transdermal delivery system comprising methylphenidate or its salt as an active ingredient. Also provided are methods of delivering a therapeutically effective amount of methylphenidate to a subject for the treatment of a disease condition. The disease condition includes a neurological condition such as Attention Deficit Disorder (ADD) and/or Attention Deficit/Hyperactivity Disorder (ADHD). Kits including the transdermal delivery system and methods of making and using the transdermal delivery system are also provided.本文揭示包含作為活性成分之哌醋甲酯或其鹽之經皮傳遞系統。亦提供向個體傳遞治療有效量之哌醋甲酯用於治療病症之方法。該病症包括神經病症,例如注意力缺失症(ADD)及/或注意力缺失/過動症(ADHD)。亦提供包括該經皮傳遞系統之套組及製備與使用該經皮傳遞系統之方法。