A metatarsal pain relief gel strip can be used to treat and/or prevent Mortons neuroma and possibly other forefoot conditions. The pain relief gel strip can include an arched or protruding gel structure that is secured within an adhesive material to allow the gel structure to be maintained on the underside of the foot between adjacent toes. Due to the arched shaped of the gel structure, when the wearer places weight on the foot, the gel structure will apply a separating force on the toes thereby relieving pressure on the nerve that runs between the toes. In this way, the pain relief gel strip can minimize the likelihood of developing Mortons neuroma, minimize pain and discomfort when Mortons neuroma has already occurred, or assist in minimizing the swelling and inflammation of the nerve.