Claude Perreault,Pierre Thibault,Sébastien Lemieux,Diana Paola Granados,Sriranganadane Dev,Mohamed Tariq Daouda,Olivier Caron-Lizotte
申请号：
US14421310
公开号：
US09500651B2
申请日:
2013.07.25
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A novel method for human minor histocompatibility antigen (MiHA) discovery, novel MiHAs identified using this method, as well as uses of the novel MiHAs, are described. One of the features of the novel method is the inclusion of personalized translated transcriptome and/or exome in the database used for peptide identification by mass spectroscopy (MS). Candidate MiHAs are identified by comparing the personalized transcriptome and/or exome to a reference genome and/or to the transcriptome and/or exome of an HLA-matched subject.
