Substitution of halogen-1,3-oxazil derivatives, Bac 1 and/or Bac2 inhibitors； uptake procedures； synthesis of drugs containing these substances； use in the treatment and/or prevention of diseases such as diabetes, Alzheimer's disease and ALS RIS, cancer, etc.
The present invention provides compounds of formula (I) having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.COMPUESTOS DERIVADOS DE HALOGENOALQUIL-1,3-OXAZINAS SUSTITUIDAS, INHIBIDORES DE LA BACE1 Y/O BACE2； PROCEDIMIENTO DE OBTENCION； COMPOSICION FARMACEUTICA QUE LOS COMPRENDE； SU USO EN EL TRATAMIENTO Y/O PROFILAXIS DE ENFERMEDADES TALES COMO DIABETES, ALZHEIMER, ALS, ENFERMEDADES AUTOINMUNES INFLAMATORIAS, CANCER, ENTRE OTRAS.
