PROBLEM TO BE SOLVED: To provide a medical equipment enabling an agent sustained release for a long period and avoidance of excessive drug release, which can hardly cause an inflammatory response, fibrotic response, etc even if the agent sustained release member stays in vivo for a long period.SOLUTION: The agent sustained release member 1 includes a first layer 10 consisting of a mixture of a biocompatibility substrate 2 and an agent 3, and a second layer 20 consisting of the same mixture as in the first layer, but the density of the agent 3 is lower than in the first layer 10.COPYRIGHT: (C)2013,JPO&INPIT【課題】長期間の薬剤徐放を可能とし、且つ使用開始直後の過剰な薬剤放出を避けることが可能であり、薬剤徐放部材、および体内に長期間留置されても、炎症反応や線維化等を起こしにくい医療機器を提供する。【解決手段】薬剤徐放部材1は、生体適合性基材2と、薬剤3とが混合されて形成された第一層10と、生体適合性基材2と薬剤3とが混合されて形成され、薬剤3の密度が第一層10よりも低い第二層20とを、備える構成とする。【選択図】図1
