This invention provides a therapeutic agent for intervertebral disk hernia having extremely low side-effects, which has a pain improvement effect for long period by only one administration, and has high curing effects and safety in clinical practice.The therapeutic agent for intervertebral disk hernia of this invention contains chondroitinase ABC as an effective component, and is used such that the component is administered into intervertebral disks of human with an amount of 1~8 units per intervertebral disk.本發明係提供一種副作用極低且僅一次的投予即得到長時間持續性之改善疼痛效果,在臨床上發揮高治療效果與安全性之椎間盤突出治療劑。本發明係關於以軟骨素酶ABC作為有效成分之椎間盤突出治療劑,其係將該成分以每一椎間盤1至8個單位投予至人類椎間盤內而使用。