PHARMACEUTICAL COMPOSITION CONTAINING PROSTAGLANDINE DERIVATIVES FOR USE IN MODULATION OF CLAUDIN-MEDIATED FUNCTIONS AND TREATMENT OF DERMATOLOGICAL DISORDERS
1. A pharmaceutical composition for treating a dermatological disease of a mammalian organism which contains an effective amount of a fatty acid derivative represented by the formula (I): wherein L, M and N are a hydrogen atom, hydroxy, a halogen atom, lower alkyl, hydroxy (lower) alkyl, lower alkanoyloxy or oxo, wherein at least one group of L and M is other than hydrogen and the five-membered ring may have at least one double bond； A is —CH, or —CHOH, —COCHOH, —COOH or a functional derivative thereof； B means single bond , -CH-CH-, -CH = CH-, -C≡C-, -CH-CH-CH-, -CH = CH-CH-, -CH-CH = CH-, -C≡C-CH- or —CH — C≡C—； Z means, or a single bond, where R and R are hydrogen, hydroxy, halogen, lower alkyl, lower alkoxy, or hydroxy (lower) alkyl, where R and R are not both hydroxy and lower alkoxy； R is a saturated or unsaturated divalent lower or middle aliphatic hydrocarbon residue unsubstituted or substituted with halogen, lower alkyl, hydroxy, oxo, aryl or heterocyclic group, and at least one carbon atom in the aliphatic hydrocarbon is not byazatelno substituted by oxygen, nitrogen or sulfur； and Ra means a saturated or unsaturated lower or middle aliphatic hydrocarbon residue which is unsubstituted or substituted by halogen, oxo, hydroxy, lower alkyl, lower alkoxy, lower alkanoyloxy, cyclo (lower) alkyl, cyclo (lower) alkyloxy, aryl, aryloxy, heterocyclic group or heterocyclic hydroxy； lower alkoxy； lower alkanoyloxy； cyclo (lower) alkyl； cyclo (lower) alkyloxy； aryl； aryloxy； a heterocyclic group； heterocyclic hydroxy. 2. Composition�1. Фармацевтическая композиция для лечения дерматологического заболевания организма млекопитающего, которая содержит эффективное количество производного жирной кислоты, представленного формулой (I):где L, M и N означают атом водорода, гидрокси, атом галогена, низший алкил, гидрокси(низший)алкил, низший алканоилокси или оксо, где по меньшей мере одна группа из L и М отлична от водорода, и пятичленное кольцо может иметь по меньшей мере одну
