Antistoffmolekyl med spesifisitet for human tumornekrosefaktor-alfa, DNA, klonings- og ekspresjonsvektor, vertscelle, fremgangsmåte for fremstilling av antistoffmolekylet samt terapeutisk preparat
King, David John,Athwal, Diljeet Singh,Brown, Derek Thomas,Weir, Andrew Neil Charles,Popplewell, Andrew George,Chapman, Andrew Paul
申请号：
NO20160694
公开号：
NO341218B1
申请日:
2016.04.26
申请国别(地区):
NO
年份:
2017
代理人:
摘要：
There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNF±. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF±.
