Ross Anthony Stewart,Natalie Jo Tigue,Lesley Lynn Young,Daniel Ramsay Higazi,Lisa Bamber,Sudharsan Sridharan,Rebecca Leyland,Nicholas Mason Durham
申请号：
US16559152
公开号：
US20200140510A1
申请日:
2019.09.03
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The disclosure provides GITRL fusion polypeptide subunits comprising an IgG Fc domain, a trimerization domain, and the receptor binding domain of GITR ligand, where the fusion polypeptide subunits can self-assemble into hexameric proteins. Also provided are methods of making fusion polypeptide subunits and hexameric proteins, and methods of use, e.g., treatment of cancer.
